Which of the following is a known cause of hirsutism?

• A. Genetics
• B. All of the above
• C. Constant rubbing of the skin
• D. Drugs for seizures

Answer: (B)

Hirsutism occurs when hair grows excessively in areas sensitive to androgens because of higher androgen activity or greater follicle sensitivity. Genetics can predispose someone to a stronger androgen response, so hair appears thicker or in more areas. Some anti-seizure medications, such as certain drugs used to treat seizures, can trigger hirsutism as a side effect by altering hormone metabolism or the way hair follicles respond. Friction from constant rubbing of the skin can also cause localized hypertrichosis, increasing hair growth in the irritated area. Because each of these factors can contribute to hirsutism, the option that includes all of them is the best choice.